JFIF ` ` ZExif MM * J Q Q Q C The aqueous solution to barrier membrane coating. /Resources 2 0 R J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Fiber supplements can lessen the absorption of some . Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. CAS #: 9004-34-6 . F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Van Veen, G.K. Bolhuis, Y.S. All Rights Reserved. Magazine: Material safety data sheet - FMC Corporation. In extrusion-spheronisation, it is the excipient of choice. Manufacturer: FMC BioPolymer. Medium size standard MCC grade, suited for the majority of directly compressible actives. It is also used in plaque assays for counting. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Synonyms: Cellulose, Cellulose powder, Cotton linters. q9;v80q>jZ /Parent 3 0 R We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. The typical mean particle size is 20200 m. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Have an order or account question? By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. If you are already a ChemPoint customer then sign up for access to our online ordering website. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Heavy metals, % NMT 0.001 Microcrystalline Cellulose (MCC) Manufacturing Industry. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. : 1. : 9004-34-6 Date Approved: 01/31/2008 . No. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. The figure below illustrates the structural organisation of cellulose within plants. 0.25 - 0.37. /Type/Page ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM All Rights Reserved. Protect them from sunshine or rain. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. PharmaCentral 2021 . Origin(s): Plant/Botanical. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. <> 130. <> MATERIAL SAFETY DATA SHEET Version: 1.0 1. ( 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 1 0 obj Revision No. Microcrystalline Cellulose (MCC) MSDS 1. 4 0 obj Avicel PC 611 (FMC Biopolymer) Supplied by. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. If breathing is difficult or if . It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. 4 0 obj METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. We respect your privacy FMC Privacy Policy. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. In 1964 FMC, Corporation . iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Your file is uploaded and ready to be published. G2W4de=u183KGH{ vQ#4:1\wc Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . % In large quantities it provides dietary bulk and may lead to a laxative effect. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Millipore. 51395-75-6 Avicel RC 591. << 0.25 - 0.37. The short-term limit for total inhalable dust is 20 mg/m3. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Cellulose microcrystalline for column chromatography. %PDF-1.4 Learn about FMC's industry leading goal of net-zero emissions by 2035. xv}O2' H~KEe9>G/,:9\i Microcrystalline cellulose -The oldest polymer finds new industrial uses,. It . Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Aqueous suspensions of microcrystalline cellulose have . CAS #: 9004-34-6 Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Remove The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. stream Test Data Available. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Avicel PH-200 microcrystalline cellulose NF, Ph. Buy Chemicals. Alginates also function as actives in some anti-reflux products. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Safety Data Sheet for Cellulose microcrystalline 102331. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Gloves, eye protection and a dust mask should be used. No. Explore how you can develop your career and bring your creative ideas to life at IFF. Molecular weight: Not Applicable 1.5. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . These, in turn, are assembled into fibrils in the cell wall. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Avicel PC 611 (FMC Biopolymer) . Are you sure you want to delete your template? No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Trademarks: Avicel PH-102. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Avicel RC-591 & CL-611 - Description. endobj Molecular Weight null. %PDF-1.5 An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Watch Now. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Well-recognized product that can do it all. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. <> DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. SUBSTANCE IDENTIFICATION 1.1. MSDS Ref. POLYOX resins are nonionic polyethylene oxide solubility polymers. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> . Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Avicel Microcrystalline Cellulose: Chemical Identifiers. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Product and Company Identification . >> Microcrystalline Cellulose Side Effects. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Looking for FMC'searnings news? /MediaBox [0 0 612 792] IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. stream Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. % Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Biologicals by FMC. % Wu, K. Zuurman, H.W. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . MCC helps in the formation of spheres because of its . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Explore how we work and why we apply science and creativity for a better world to everything we do. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe % 1. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Learn about FMC's differentiated biologically-based crop solutions. Avicel PC 611 Microcrystalline Cellulose. Microcrystalline Cellulose / Avicel PH-102. q9;v80 Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. endobj CoA. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. INCI. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. <> LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. (1962). Product Name: Microcrystalline Cellulose 1.2. Microcrystalline Cellulose. q86@on$^X_HuH;3` For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content.
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